Wellbutrin Dosage Guide

Important Info For Wellbutrin Users

Finding the best Wellbutrin dosage often depends on individual factors such as age, other medical conditions one may have, overall physical condition, and other medications one may be taking.

What Is Wellbutrin?

Wellbutrin is a prescription medication used to treat depression, anxiety, smoking cessation and other conditions.

It elevates mood and interacts with the areas of the brain responsible for symptoms of depression.

It is also used by folks with co-occurring disorders such as those who suffer from depression and conditions such as Attention Deficit Hyperactivity Disorder (ADHD).

Wellbutrin Dosage Guidelines

Wellbutrin comes in regular, sustained-release form (SR), and extended release (ER) form. The regular version is available in 75, 100, and 150 mg tablets and the sustained release tablets are available in 100 mg, 150 mg, and 200 mg.

The extended release tablets are available in 150 mg and 300 mg form.

Generally speaking, this drug be prescribed to be taken one, two or three per day depending on the condition. For immediate-release tablets, no single dose should exceed 150 mg and each dose should be separated by 6 hours.

For depression, for example, the recommended dose of immediate release tablets is 100 mg 3 times daily with a maximum dose of 450 mg daily. The starting dose is 100 mg twice daily and the dose may be increased to 100 mg 3 times daily after three days.

For the sustained release tabs, the initial dose typically 150 mg once daily up to 150 mg twice daily. However, the max dose generally does not exceed more than 400 mg total per day. Extended release tablets are administered once daily.

Side Effects

Wellbutrin side effects may include agitation, dry mouth, insomnia, headache, nausea, constipation, and tremors. Also, there is a link between Wellbutrin and weight loss. More serious be rare symptoms may include manic episodes, hallucinations, seizures, and increased risk of suicide.

Withdrawal Risk

Abruptly stopping this medication may result in withdrawal symptoms. Read this important warning about Wellbutrin withdrawal.


For women who are pregnant or thinking about becoming pregnant while taking this medication, read about the risks of combining antidepressants and pregnancy. Inform your prescribing doctor immediately, and discuss your options. For nursing mothers, Wellbutrin is secreted in breast milk.

Safety Tips

The tablets should be kept and stored at room temperature. Never adjust your dosage without first consulting with your doctor. Never skip or take a double Wellbutrin dose. Always take this medication as prescribed under the supervision of a medical professional. 

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