Serzone Overview By Dr. Kensington

Important Info For All Users

Serzone (nefazodone) is an antidepressant medication. It works by interacting with the chemicals in the brain that contribute to the symptoms of depression.

Depression symptoms include feelings of sadness, worthlessness, guilt, loss of interest in daily activities, changes in sleep and appetite, fatigue, insomnia or sleeping excessively, and thoughts of death or suicide.


A common starting dose of this medication is 200 mg per day, typically split into two doses during the day.

A common maintenance dose is between 300 to 600 mg/day. It is important to remember that it may take several weeks before the full antidepressant effects become apparent.

Side Effects

Side effects may include nausea, dizziness, fatigue, insomnia, dry mouth, constipation, and blurry vision. For additional information, read this helpful overview of effects of antidepressants. Notify your doctor right away if you experience any adverse side effects.


Prior to taking this medication, inform your doctor if you have recently taken an MAO type medication. You will have to wait 14 days after taking an MAO medication before taking Nefazodone. Similarly, you must stop taking this medication for 14 days before taking an MAO. Also, notify your doctor if you have liver disease. Your doctor may need to monitor your liver function while you are taking this drug.

Pregnancy Warning

If you become pregnant while taking antidepressants, inform your doctor immediately. See this warning about antidepressants and pregnancy.

Suicide Warning

When taking antidepressants, there may be an increased risk of suicidal thoughts and behaviors in some patients taking them, particularly younger patients. Read this important warning about antidepressants and suicide.

Alcohol Warning

Never mix antidepressants with alcohol. Alcohol is a depressant that should not be used by those already suffering from depression. In addition, both substances hinder one's ability to operate heavy machinery. Driving is not advised after consuming either antidepressants or alcohol. For more information, read this warning about antidepressants and alcohol.

Serzone Safety Tips

Only use prescription medications under the supervision your doctor. Follow all prescriptions exactly; do not skip doses, or double up doses.

If you have any questions about your dosage or possible side effects or drug reactions, contact your prescribing doctor right away.

Report all side effects to your doctor. Seek emergency medical attention if you experience any severe or unusual side effects.

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